SLC12A1 and kidney disorder: Inactivating NKCC2 mutations causes antenatal Bartter syndrome type-1, a life-threatening kidney disease which is diagnosed usually in the antenatal period, due to the presence of fetal polyuria leading to polyhydramnios and preterm labor, salt loss, hypokalemia, metabolic alkalosis, hypercalciuria, and nephrocalcinosis [5,6].