CD8A and breast cancer: In AIE, the proportion of CD8 T cells, NK cells, and M1 macrophages cells were higher than AEE, while the proportion of M2 macrophages cells and M0 macrophages cells was lower than AEE (p < 0.05); In luminal B, the proportion of BEE in M1 macrophages infiltration was lower and the proportion of BIE in CD8 T cells infiltration was higher, which was suspected to be related to the anti-tumor ability of “epithelial cell-enriched” was worse, and “immune cell-enriched” corresponded to T cell immunity in luminal BC (Figure 4A).