A previous study showed that presenilin-1-associated gamma-secretase activity localized to lipid raft complexes can trigger release of the Neogenin intracytoplasmic domain, which presumably leads to increased aggressiveness in ganglioside-positive melanoma cells, suggesting that presenilin-1 may regulate Neogenin-dependent melanoma aggressiveness [35]. This evidence concerns the gene NEO1 and melanoma.