CDH2 and melanoma: Our results show that treatment of C8161 and Sk-Mel28 aggressive melanoma cells with 200 ng/mL of rhNetrin-1 was associated with a significant increase in N-cadherin expression (C8161: 1.19 +/− 0.05-fold of control; Sk-Mel-28: 1.43 +/− 0.12-fold of control) (Figure 3C,D, p < 0.05).