NTN1 and melanoma: In addition, although there was no statistical significance between the different anti-Neogenin treatment groups for C8161, migration of Sk-Mel28 aggressive melanoma cells towards the Netrin-1-expressing SH-SY5Y was significantly lower when treated with 25 μg/mL compared to 5 μg/mL of anti-Neogenin (Figure 4B, p < 0.05).