In fact, we demonstrated that the Neogenin receptors expressing aggressive melanoma cells, C8161 and Sk-Mel28, which also showed a significantly greater ratio of Neogenin to Netrin-1 expression, demonstrated significantly increased migration towards exogenous, soluble rhNetrin-1 and, most importantly, towards Netrin-1-expressing cells compared to control. The gene discussed is NTN1; the disease is melanoma.