In this study, activation of aSMase in response to the interaction between EGCG and the 67-kDa laminin receptors (67LR) altered lipid-raft clustering [371] and inhibited the prosurvival activity of tyrosine kinase receptors both in primary multiple myeloma cells and in the multiple myeloma cell line, U266 [348]. This evidence concerns the gene NTRK1 and plasma cell myeloma.