Consistent with the inhibition of AC, SACLAC decreased S1P and increased ceramide levels, and induced cell death of AML cells lines HL-60/VCR, THP-1, and OCI-AML2, as well as a 75% reduction in the leukemic burden of AML xenograft in NSG mice [156]. Here, RUNX3 is linked to acute myeloid leukemia.