CGAS and colorectal cancer: Fluorescent biosensors made by monitoring the activity of PPases can be utilized to screen for potential inhibitors of PPases, which are associated with many clinical diseases (lung cancer and colorectal cancer, etc.)[35,36,37]; In laboratory studies, using pyrophosphatase-coupled assays to monitor enzymatic activity is a potential application of PPases, such as assays of the activity of arginase, cyclic GMP-AMP synthase, and santalene synthases [38,39,40]; PPases can also be applied in industry to increase the yield of UDP-sugar synthesis and the amplification efficiency of PCR.