In this study, we evaluated the potential of LM-031 and its analogues LMDS-1 to -4 in treating tauopathies by examining if these compounds exert neuroprotective effects through enhancing TRKB signaling in ΔK280 tauRD-DsRed folding reporter SH-SY5Y cells. Here, NTRK2 is linked to tauopathy.