Tissue samples from the CNS lesions of MS patients showed increased expression of FLIPL (a long-form of FLIP), an inhibitor of caspase-8 activation, which might stimulate the cleavage of caspase-8 to produce a p43 subunit but blocking full caspase-8 activation and by subsequently inducing the activation of necroptosis [69]. Here, CASP8 is linked to myeloid sarcoma.