Moreover, in high fat diet (HFD) or methionine-choline deficient (MCD) diet-fed mice that serve as a model of NAFLD and NASH, expression of TNF-α, RIPK3, and MLKL were increased in the liver, which contributes to liver injury, fibrosis, and inflammation [101,102]. Here, RIPK3 is linked to metabolic dysfunction-associated steatohepatitis.