Apart from the above Hsp90 inhibitors, other small molecules, namely necroptosis-blocking compound 1 (NBC1) and JG-98, were identified, which seemed to inhibit allosteric transition in Hsp70 by covalently binding, due to which Hsp70 loses the capability to promote MLKL polymerization, and which finally caused necroptosis inhibition in human ND and cancer [27,230]. The gene discussed is MLKL; the disease is cancer.