Earlier studies had shown that TNF/TNFR1-mediated necroptotic neuronal and oligodendrocyte losses were associated with the increased expression of RIPK1 and phosphorylation levels of RIPK3/MLKL in in vitro and in vivo MS models, rather than apoptotic signaling [69,73]. The gene discussed is MLKL; the disease is myeloid sarcoma.