Concurrently, Chen et al. [116] observed that CSE-induced necroptosis (higher p-MLKL level) secretes HMGB1 along with an increase in TNF-α, IL-6, and IL-1β, resulting in inflammation and COPD progression in CS-exposed lung epithelial cells/organoids and mouse tissues. The gene discussed is MLKL; the disease is chronic obstructive pulmonary disease.