Moreover, a novel RIPK3/NRLP3 complex, which is generally involved in caspase-1 activation, IL-1α/β and IL-18 secretion, was observed in the THP-1 macrophages of an ATP- and LPS-induced ALI mice model, suggesting that RIPK3-mediated inflammasome activation and necroptosis processes are mutually co-regulated in the pathophysiology of lung injury [97]. Here, IL18 is linked to acute respiratory distress syndrome.