In contrast, Ni et al. [103] found that in the diet-induced hepatic steatosis model, RIPK3-KDKI or RIPK3-KO mice show protective effects against liver I/R injury in the late phase but not in the early phase, whereas MLKL−/− mice were protected from hepatic I/R injury in both early and late phases. This evidence concerns the gene RIPK3 and fatty liver disease.