Moreover, the clinically used anti-convulsant, phenytoin, as well as natural compounds found in different plants (wogonin and fluorofenidone), were found to ameliorate renal injuries in cisplatin- and IRI-induced AKI mice models by inhibiting RIPK1 kinase activity and blocking RIPK1/-3/MLKL phosphorylation [232,233,234]. This evidence concerns the gene MLKL and acute kidney injury.