RIPK3 and neoplasm: Similarly, Schmidt et al. [139] described that RIPK3 upregulation released interleukin-1α (IL1-α) from Poly I:C-induced necroptotic cervical cancer cells and activated DCs; these DCs then showed their anti-tumor effects by producing cytotoxic cytokine IL-12 or by activating CD8+ T-cells [187].