CASP8 and cancer: In addition, delivery of engineered self-tumor-derived exosomes with CRISPR/Cas9 vectors triggered necroptosis in cancer cells via activation of TNF-α receptor signaling pathways together with impairment of caspase-8 and IAP1/2 genes expression, resulting in the induction of necroptotic cell death concurrent with the production of anti-tumor immunity against cancer cells [299].