Moreover, RIPK3−/− and MLKL−/− also show reduced NRLP3 inflammasome activation and IL-1β secretion during I/R response, which implies that a “necroinflammatory” cycle is involved in the reciprocal stimulation of both necroptosis and NLRP3 inflammasome activation and possibly underlies the transition from AKI to chronic kidney disease (CKD) [97]. This evidence concerns the gene MLKL and chronic kidney disease.