RIPK3 and neoplasm: In addition, RIPK3 expression also induced natural killer (NK) T-cells-mediated immune response via the activation of mitochondrial PGAMF-NFAT/Drp1 signaling, independent of the necroptosis pathway, and that anti-tumor response of NK T-cells to metastatic cancer cells is diminished in RIPK3−/− mice [141].