Werthmöller et al. [140] reported that treatment in combination of with the zVAD-fmk, a pan-caspase inhibitor that induces necroptosis, and other therapeutics, such as chemotherapy, radiotherapy, and hyperthermia, to B16 melanoma cells markedly inhibits tumor growth by decreasing infiltrated regulatory T-cells while increasing cytotoxic DCs as well as CD8+ T-cells infiltration around the tumor microenvironment. This evidence concerns the gene CD8A and neoplasm.