Alternatively, the disruption of the normal placental function and a reduced integrity of the placental barrier due to fetal malformations could lead to a higher mother-to-fetus transport of pregnancy hormones and other endocrine disruptors [17,18,19], why AFP levels in this context may represent an indirect marker of the possible contribution of other factors to the risk of testicular cancer in later life. The gene discussed is AFP; the disease is testicular cancer.