INS and hyperinsulinism: For their part, Alonso-Magdalena et al. (2006) [45] reported that exposure of adult mice to a low BPA dose (10 mg/kg) triggered an increase in plasma insulin, and saw that a more prolonged exposure produced an increase in the insulin content in ß pancreatic cells in response to a stimulus of its oestrogen receptors with the mice developing chronic hyperinsulinism.