Moreover, ACE-2 receptors, which facilitate the entry of SARS-CoV-2 within host target cells, are produced at a much lower rate in women due to their relationship with estrogen, [15] while levels of proinflammatory cytokines, such as CRP (C-reactive protein) and different interleukins, and even “cytokine storms” are increased due to the reduction intestosterone among aging men, thereby worsening the progression and severity of COVID-19 among this group [15,16]. Here, CRP is linked to COVID-19.