THBD and chronic kidney disease: Similarly, Drożdż D. et al. evaluated thrombomodulin as a marker of endothelial dysfunction in 59 children with CKD 1–5, and Makulska I. et al., tested skin autofluorescence (sAF), a marker of the accumulation of advanced glycation end products, as a vascular damage indicator in 76 children with CKD [45,46].