CFTR and cystic fibrosis: We report the case of an 11-year-old Caucasian child diagnosed with CF and PI based on positive NBS [25] (blood immunoreactive trypsinogen 105 ng/mL, CFTR genotype: F508del/L1065P, sweat chloride: 112–114 mEq/L), followed at the CF Center of Florence, Italy.