We report the case of a 13-year-old Caucasian child diagnosed with CF and PI based on positive newborn screening (NBS) [25] (immunoreactive trypsinogen 103 ng/mL, CFTR genotype: R1162X/R553X, sweat chloride: 105–106 mEq/L) and followed at the CF Center of Florence, Italy. This evidence concerns the gene CFTR and cystic fibrosis.