In particular, Khan et al. [69] recently suggested conducting genetic testing for a CFEOM-like phenotype before general anesthesia to exclude pathogenic mutations in RYR1 (OMIM #180901), which was documented to be associated with congenital ophthalmoplegia, ptosis with facial weakness, and malignant hyperthermia [70,71]. Here, RYR1 is linked to congenital fibrosis of the extraocular muscles.