COL1A1 and osteogenesis imperfecta: The two VUS were paternally inherited missense variants in the COL1A1 gene related to autosomal dominant forms of osteogenesis imperfecta (OMIM 166210) and paternally inherited nonsense variant in the COL10A1 gene related to autosomal dominant metaphyseal chondrodysplasia Schmid type (OMIM 156500).