Literature data include three cases with LCR B–D+ (deletion between ZNF74 and HIC2 probes) and clinical features include: ventricular septal defect, cleft lip, and palate, retrognathia, hyper nasal speech, dysmorphic face, short stature, moderate ID and ADHD [11]. The gene discussed is ZNF74; the disease is attention deficit-hyperactivity disorder.