TBX5 and Global developmental delay: For example, the haploinsufficiency of T-box transcription factor 5 (TBX5) leads to congenital heart disease [35]; the haploinsufficiency of proline-rich 12 (PRP12) causes neurodevelopmental and eye diseases [36]; SHANK3 mutations predispose to autism [37]; SETD1A is linked with neurodevelopmental disorders [38]; a SOX5 haploinsufficiency is linked with neurodevelopmental disorders, intellectual disabilities, and language delays [39]; a BAZ1B haploinsufficiency is linked with neurodevelopmental disorders [40]; and the haploinsufficiency of PUM1 causes developmental delays and seizures [41].