For example, Temozolomide (TMZ)-resistant glioblastoma cells confer TMZ chemoresistance to receptor TMZ-sensitive cells in an exosomal miR-151a loss-dependent manner, so miR-151a mimics transfected into glioblastoma cell lines can sensitize TMZ-resistant GBM cells via inhibiting XRCC4-mediated DNA repair [199]. Here, XRCC4 is linked to glioblastoma.