For example, 21 nt i-tRF-Gly interacts with hnRNPL and then prevents phosphorylation of hnRNPL by AKT2, thereby reducing the AKT2-hnRNAPL-DDX17 axis and attenuating the malignant phenotype in pancreatic cancer cells [81]. The gene discussed is HNRNPL; the disease is familial pancreatic carcinoma.