GO function, PPI network, and lncRNA-miRNA-mRNA network identified several DEmRNAs such as SLC25A4, PLCB1, AGTR2, PRKN, and SCD5 were possibly associated with new-onset T2DM, and miR-199b-5p, miR-202-5p, miR-548o-3p as well as miR-1255b-5p could be involved in their regulation. This evidence concerns the gene PLCB1 and type 2 diabetes mellitus.