Currently, there are ongoing clinical trials, phase Ib/II DESTINY-BREAST07 (NCT04538742) and phase Ib DESTINY-BREAST08 (NCT04556773), that are investigating the anti-tumor activity of T-DXd in combination with other therapies in patients with HER2-positive metastatic breast cancer or metastatic HER2-low advanced or metastatic Breast Cancer, respectively. This evidence concerns the gene ERBB2 and neoplasm.