In addition, Prx1 shows abnormal expression in several human cancers, including lung, breast, and prostate cancers, as well as modulates various ROS-mediated signaling pathways, such as phosphatase and tensin homolog (PTEN) and mammalian Ste20-like kinase-1 (MST) [1,3,4]. The gene discussed is PTEN; the disease is prostate carcinoma.