RPRM and neoplasm: Garcia-Bloj et al. [43], by comparing the ZFN, TALENs, and CRISPR technologies for the overexpression of tumor suppressors in GC strains, demonstrated that CRISPR-dCas9 can restore the expression of the MASPIN/REPRIMO genes, being considered a transient, targeted, and efficient tool for restoring tumor suppressor functions.