As regards SCN1A, the splice-site c.695-1G>A variant was identified at the heterozygous state; it affects a splice acceptor site, is predicted as damaging by the in silico tools DANN and dbscSNV scores, and has already been reported as possibly associated with Dravet syndrome (MIM: #607208) [27]. Here, SCN1A is linked to encephalopathy, progressive, early-onset, with brain edema and/or leukoencephalopathy.