In these situations, there is an increase in cytokines, such as TNF-α, IL-1β, and TGF-β, which can induce the expression of the CYP27B; additionally, higher values of the calcitriol/calcidiol ratio and calcitriol levels have been observed in patients with these diseases compared to healthy subjects [49], similar to the pattern observed in our study where patients with SLE also have an inflammatory process. The gene discussed is TNF; the disease is systemic lupus erythematosus.