Of particular interest for HNSCC are the nuclear receptor binding SET domain (NSD) 1 (NSD1), NSD2, and NSD3 protein lysine methyltransferases that mono- and di-methylate lysine 36 of histone H3 (H3K36) [8,9,10,11,12,13,14,15]. Here, NSD2 is linked to head and neck squamous cell carcinoma.