NSD1 and NSD3 are amongst the top ten most frequently genetically altered genes in HPV-negative HNSCC, with NSD1 carrying mutations and NSD3 coamplifying with fibroblast growth factor receptor 1 (FGFR1) (8p11-12 amplicon) in HPV-negative HNSCC [16]. This evidence concerns the gene NSD3 and head and neck squamous cell carcinoma.