ITK and acute myeloid leukemia: Notably, our results demonstrate downregulation in T cell co-stimulation molecules (HLA class II regulators [CIITA, IRF8, IRF4], the T cell receptor-signaling pathway [CD247, CD3E, CD3G, ITK], activated molecules [LAT2, TNFSF4, IFNG, IL15]) and the up-regulation of inhibitory T cell ligand (PVR) in the RE group, which are known to drive relapsed AML cells to evade from immune control (Figure 6A,B).