Notably, our results demonstrate downregulation in T cell co-stimulation molecules (HLA class II regulators [CIITA, IRF8, IRF4], the T cell receptor-signaling pathway [CD247, CD3E, CD3G, ITK], activated molecules [LAT2, TNFSF4, IFNG, IL15]) and the up-regulation of inhibitory T cell ligand (PVR) in the RE group, which are known to drive relapsed AML cells to evade from immune control (Figure 6A,B). This evidence concerns the gene LAT2 and acute myeloid leukemia.