It was shown the highest activity of PON1(P) in the blood of AP patients with the AG genotype, which was statistically significant to AP patients with the GG (p = 0.0274 and p = 0.0123 on the third and seventh days of hospitalization, respectively) and AA genotypes (p = 0.0369 and p = 0.0475 on the third and seventh day of hospitalization, respectively). The gene discussed is PON1; the disease is alkaline phosphatase measurement.