It was shown that PON1(P) and PON1(L) activities in the serum of AP patients were lower compared to healthy subjects in the case of individuals with the TT (p = 0.0047 and p = 0.0048, respectively) and TC genotypes (p < 0.0001 and p = 0.0111, respectively) for SNP rs662 in the PON1 gene. This evidence concerns the gene PON1 and alkaline phosphatase measurement.