PON1 and alkaline phosphatase measurement: However, in the group of smoking AP patients with the TT genotype, gradual decreases of the PON1(P), PON1(A), and PON1(L) activities were shown (p = 0.0458, p = 0.0376, and p = 0.0329, respectively, for comparison of the first and seventh day of hospitalization) in contrast to smoking AP patients with the TC genotype, where no changes in these parameters were found.