SULT2B1 and prostate intraepithelial neoplasia: Cholesterol sulfate was produced by hydroxysteroid sulfotransferase 2B1 (SULT2B1) and accumulates in human prostate adenocarcinoma and precancerous prostatic intraepithelial neoplasia (PIN) lesions, which indicates the functional roles of cholesterol sulfate in these diseases [42].