Intravenous injection of miR-21 antagomir improved insulin sensitivity and lowered levels of serum TG, total cholesterol [10], low-density lipoprotein cholesterol (LDL-CHO), and high-density lipoprotein cholesterol (HDL-CHO) in a streptozotocin-induced type 2 diabetes mellitus rat model, as is partially mediated by TIMP metallopeptidase inhibitor 3 (Timp3), a direct target of miR-21 [25]. This evidence concerns the gene TIMP3 and type 2 diabetes mellitus.