AKT1 and malignant colon neoplasm: Intestinal EVs were found to stimulate Akt/mTOR pathway. EVs derived from human colon epithelial cell line NCM460 or colon cancer (CC) cell line SW620 promoted the migration of colon adenocarcinoma SW480, the effect of which was mediated by the activation of the epithelial–mesenchymal transition process and the Akt/mTOR signaling pathway [75].