In light of the therapeutic actionability of pathogenic and likely pathogenic (P/LP) CHEK2 variants in metastatic castration-resistant prostate cancer (mCRPC) [8], the identification of germline variants that not only predict the disease risk, but also have implications for the clinical outcome, has increasing relevance, especially since recent large-scale analyses have demonstrated that P/LP variants in cancer susceptibility genes are identified in more than 50% of the cases who do not meet formal germline testing criteria [9]. Here, CHEK2 is linked to cancer.