This exploratory study showed that four polymorphisms associated with COVID-19 severity (ACE2 rs2285666, ACE2 rs2074192, TMPRSS2 rs12329760, and TMPRSS2 rs2070788), did not appear to predispose for the development of long-COVID symptoms in previously hospitalized COVID-19 survivors. The gene discussed is TMPRSS2; the disease is COVID-19.