The meta-analysis by Saengsiwaritt et al. revealed an association between the C allele of the TMPRSS2 rs12329760 (OR 1.32, 95% CI 1.01–1.73) and the T allele of ACE2 rs2285666 (OR 2.14, 95% CI 1.26–3.66) with a higher risk of severe COVID-19 [11]. The gene discussed is ACE2; the disease is COVID-19.