Purines are basic components of nucleotides in cell proliferation; thus, impaired purine metabolism is associated with the progression of cancer, membrane trafficking (p = 1.999 × 10−6), which is a focal point for targeting cancer [77], negative regulation of the protein modification process (p = 3.963 × 10−6), vesicle organization (p = 5.970 × 10−6), PID MTOR 4PATHWAY (p = 1.629 × 10−5), negative regulation of apoptotic signaling pathway (p = 1.897 × 10−5), malignant pleural mesothelioma (p = 2.421 × 10−5), adipogenesis (p = 2.489 × 10−5) and brain development (p = 2.630 × 10−5). The gene discussed is MTA2; the disease is malignant pleural mesothelioma.