Tang et al. found that hsa-miR-139-5p increased apoptosis and inhibited cisplatin (DDP), induced non-small cell lung cancer (NSCLC) cell proliferation in vitro by regulating the PI3K/AKT/caspase-3 signaling pathway, and sensitized NSCLC cells to DDP by targeting HOXB2. This evidence concerns the gene HOXB2 and non-small cell lung carcinoma.