Conlon et al. predicted that the hnRNP H binding to the RNA G-quadruplex forming expanded C9ORF72 repeats results in exon skipping and disruptive splicing, leading to the accumulation of hnRNP H/RNA G-quadruplex aggregates in the brain and causing ALS/FTD [93]. This evidence concerns the gene HNRNPH2 and frontotemporal dementia.