TNF and Chronic colitis: In addition, Cui et al. reported that intraperitoneal administration of magnesium isoglycyrrhizinate (5 mg/kg BW) alleviated acute and chronic colitis by reducing immune cell infiltration and suppressing pro-inflammatory cytokine (IL-1β, IL-6, IL-17, IFN-γ, and TNF-α) production in DSS-induced colitis mice [62].