Chronic intestinal inflammation is recognized to enhance Wnt/β-catenin signaling though inflammatory signaling pathways, including NF-κB, mitogen-activated protein kinase (MAPK), protein kinase B (PKB/AKT), and signal transducer and activator of transcription (STAT) signaling, which further activate cell proliferation and CRC development [50]. Here, WNK2 is linked to colorectal carcinoma.