Administration of ferulic acid (20 and 40 mg/kg BW) for 14 weeks decreased myeloperoxidase levels, down-regulated mRNA expression of TNF-α, IL-1β, IL-6, i-NOS, and COX-2, up-regulated IL-10 mRNA expression, and restored histopathological aberrations in colon tissues in trinitrobenzene sulfonic acid-induced ulcerative colitis in rats [53]. Here, PTGS2 is linked to ulcerative colitis.