A similar study demonstrated that administration of phytic acid at doses of 0.25, 0.5, and 1 g/kg BW per day by gavage for 39 weeks decreased tumor incidence and reduced serum levels of pro-inflammatory cytokines (TNF-α, IL-1β, and IL-6) in a 1,2-dimethylhydrazine-induced rat colorectal cancer model. This evidence concerns the gene TNF and colorectal cancer.