Previous studies have shown that primary colonic IECs have a greatly different response to inflammation compared with other cancer cell lines when studying colitis, as shown in the fact that IFN-γ can induce the secretion of IL-8 in Caco-2 cells to remain unchanged, while it increases in HT-29 cells and decreases in primary IECs [31]. This evidence concerns the gene CXCL8 and colitis.