The SOD activities in colon tissues significantly reduced in the HFD group and the HFD + NPs group compared with those in the control group, whereas B. coagulans intervention increased the SOD activities to a level similar to that of the control group, as shown by the SOD activities of the HFD + NPs + BC group and the HFD + NPs + BC group. The gene discussed is SOD1; the disease is breast cancer.