AKT1 and cancer: These compounds induce remarkable effects against human cancers by acting on molecular targets, notably by reducing the expression of a transcription factor regulating the expression of cytoprotective genes, reducing p53 activation, decreasing Bcl-2 expression and mitochondrial membrane potential, suppressing the expression of HIF-1α, and increasing cellular apoptosis with the downregulation of p-Akt expression [10,11].