CDKN1B and Familial prostate cancer: To show the beneficial effects of Quercetin against prostate cancer, Erdogan and colleagues showed that this substance, at a dose of 40 Μm, upregulates Bax, Bcl-2, p21Cip1, p27Kip1, and Cyt c, caspase 3, caspase 8, and p53.