The results of a study by McLarty et al., conducted on 26 men with positive prostate biopsies, showed that treatment with polyphenol E (800 mg EGCG for a total of 1.3 g of green tea) led to a significant reduction in serum levels of PSA, HGF, and VEGF, thus suggesting the efficacy of polyphenol E in the treatment or prevention of prostate cancer [136]. Here, KLK3 is linked to Familial prostate cancer.