There is no cure for chronic lymphocytic leukemia (CLL) with current chemotherapy treatments; however, Curcumin was found to induce apoptosis in B-cell chronic lymphocytic leukemia (B-CLL) via the upregulation of the proapoptotic protein BIM, and the downregulation of the AKT, STAT3, and XIAP (X-linked inhibitor of apoptosis) proteins and NF-κB [95]. Here, STAT3 is linked to B-cell chronic lymphocytic leukemia.