In contrast to these data, overexpression of OGA in cardiomyocytes (cmOGA-Tg) results in reduced O-GlcNAcylation and slight cardiac hypertrophy that is not accompanied by enhanced expression of natriuretic peptide alpha (Nppa) and myosin heavy chain 7 (Myh7; markers of pathologic hypertrophy) [92]. The gene discussed is MYH7; the disease is cardiac hypertrophy.