Notably, viral delivery of OGA to the heart protected against the development of diabetic cardiomyopathy, and this was correlated with decreased cardiac hyper-O-GlcNAcylation of phosphatidylinositol-3-kinase (PI3K), protein kinase B (AKT), and sarco/endoplasmic reticulum Ca2+-ATPase (SERCA2A) [107]. This evidence concerns the gene AKT1 and diabetic cardiomyopathy.