By using unbiased array-based DNA methylation and mRNA expression profiling approaches, we were able to show strong enrichment of differentially methylated heat shock factor 1 (HSF1) binding sites (>400-fold) in liver tissue of NAFLD patients in the process of liver remodeling after significant weight loss following bariatric surgery [10]. Here, HSF1 is linked to metabolic dysfunction-associated steatotic liver disease.