Encoded by LGALS3, there is some evidence to suggest LGALS3 is a T1D susceptibility gene [131] and this has been supported by a small number of in vitro and in vivo studies suggesting a role for galectin 3 in cytokine mediated β-cells apoptosis and survival [131,132,133]. The gene discussed is LGALS3; the disease is type 1 diabetes mellitus.