Because mutations or dysfunctions of 14-3-3 proteins or abnormalities of the 14-3-3 PPIs contribute to many pathologies and disorders [22,23], 14-3-3 proteins are regarded as the therapeutic targets in many non-cardiac diseases, most of which are metabolic or age-related diseases, e.g., Parkinson diseases, Alzheimer disease and cancers [22,23,24]. The gene discussed is YWHAQ; the disease is early-onset autosomal dominant Alzheimer disease.