Correspondingly, both Gucy2e and Pdc were significantly connected to the phototransduction canonical pathway, and the increment in Gucy2e protein expression was also implicated in mediating the vision function together with Crybb2 in the ω-3 PUFA-fed KO mice, corroborating the findings of Georgiou and Prokopiou, where AMD patients supplemented with EPA and DHA demonstrated a significant improvement of vision [85]. This evidence concerns the gene CRYBB2 and age-related macular degeneration.