In the late phase, within 4 weeks, improved insulin resistance was maintained after 4 weeks of D-LED PBM based on HOMA-IR (Figure 3C) and increased expression of insulin in IHC of the pancreas after 4 weeks of D-LED PBM (Figure 3B) as multifactorial effects may potentiate reductions in the serum glucose level. Here, INS is linked to Insulin resistance.