In T lymphocytes, the LRRC8 protein transports cGAMP resulting in STING activation and p53-mediated apoptosis [45] LRRC8 deficiency enhances T cell-mediated antiviral immunity to influenza as well as to central nervous system inflammation in the experimental autoimmune encephalomyelitis (EAE) model [45]. This evidence concerns the gene LRRC8A and experimental autoimmune encephalomyelitis.