In T lymphocytes, the LRRC8 protein transports cGAMP resulting in STING activation and p53-mediated apoptosis [45] LRRC8 deficiency enhances T cell-mediated antiviral immunity to influenza as well as to central nervous system inflammation in the experimental autoimmune encephalomyelitis (EAE) model [45]. The gene discussed is LRRC8A; the disease is influenza.