Its expression, as well as that of Gal-4, is increased in multiple sclerosis brain tissue [40,47] and down-regulated in the hippocampus of schizophrenia patients [48], but studies involving Gal-8 KO mice have mainly focused the roles of Gal-8 in cancer or immunity [49,50] neglecting possible neurologic implications. Here, LGALS4 is linked to multiple sclerosis.