In the process of detaching from the ECM, activated integrin clusters at the site of cancer cell–ECM adhesions are endocytosed into endosomes, and then recruit focal adhesion kinase (FAK) in the cytoplasm to localize on endosomes, producing an endosomal platform to support the survival of cancer cells after integrin signaling away from the plasma membrane [11] and to facilitate their metastasis. The gene discussed is PTK2; the disease is cancer.