Jump-starting the ongoing interest in the intriguing role of mitoferrins in the development, progression, and treatment resistance of cancer cells, in 2013, Hung et al. discovered that mitoferrin-2 is upregulated in head and neck cancer cells that are sensitive to radiation and actually confers this sensitivity by increasing the mitochondrial uptake of iron and, thus, mitochondrial dysfunction [75]. The gene discussed is SLC25A37; the disease is head and neck cancer.