A transcriptome-wide analysis of MIA pancreatic cancer cells stably overexpressing the RNA m6A demethylase ALKBH5 revealed that ALKBH5 regulated the methylation of SLC25A28, enhancing the RNA stability, as well as the methylation and alternative splicing of SLC25A37, leading to upregulation of the respective mitoferrin proteins. Here, ALKBH5 is linked to familial pancreatic carcinoma.