Specifically, Zhang et al. recently reported that the glycolytic enzyme α-enolase 1 (ENO-1) inhibits the expression of mitoferrin-1 by reducing IRP1 mRNA expression, which in turn prevents the transcription of SLC25A37 by CREB, ultimately reducing ferroptosis in hepatocellular carcinoma cells [32]. Here, ENO1 is linked to hepatocellular carcinoma.