Considering the established connections between mitochondrial dysfunction and disrupted iron homeostasis and a variety of pathologic conditions, including atherosclerosis, type 2 diabetes, neurodegenerative diseases such as Parkinson disease, Alzheimer disease, and amyotrophic lateral sclerosis, and cancer progression and resistance to treatment among others [50,51,52,53,54,55,56,57], it is not surprising that research is uncovering similar connections to the absence or dysfunction of mitoferrins. The gene discussed is SLC25A37; the disease is early-onset autosomal dominant Alzheimer disease.