Moreover, our results show that miR-574-3p downregulates VEGF expression by targeting hnRNP L. miR-140-3p and miR-574-3p combined treatment inhibited VEGF expression in umbilical vein endothelial cells more significantly than miR-140-3p or miR-574-3p alone; thus, the reduced levels of miR-140-3p and miR-574-3p offset the inhibition of VEGF expression, resulting in placental-derived exosome-mediated fetoplacental endothelial dysfunction in GDM. The gene discussed is HNRNPL; the disease is gestational diabetes.