Previous research has shown that the aggregation of chemerin in fetal brain tissue leads to cognitive impairment in GDM offspring; chemerin buildup induces macrophage recruitment and pyroptosis, which is characterized by the activation of caspase-1 and secretion of pro-inflammatory cytokines such as IL-1β and IL-18 [20,32]. This evidence concerns the gene RARRES2 and Cognitive impairment.