Figure 3B shows that chemR23 in placental tissue changes in response to successful knockdown of chemR23. We observed that the levels of miR-140-3p and miR-574-3p were decreased in placenta-derived exosomes from chemerin-induced GDM mice, and increased in GDM mice with chemR23 knocked down (Figure 3C). Here, CMKLR1 is linked to gestational diabetes.