HSF4 and myopia: Notably, Egr1, the most abundantly expressed IETF at the mRNA level (Table 3) which also upregulates at the protein level at 6 h PCS (Figure 4), is a negative regulator of myopia [58] whose expression upregulates in the lens following selenite stress [59] as well as Hsf4 [60] and β1-integrin gene deletion [61].