CAT and cancer: To balance the redox state, KRAS-mutant cancer cells display upregulation of major antioxidant enzymes (peroxiredoxin 3, thioredoxin peroxidase, catalase) and reduced glutathione (GSH) levels, as well as enhanced detoxification pathways and resistance to apoptotic death in response to oxidative compounds such as hydrogen peroxide (H2O2) [84].