SQSTM1 and hydrops fetalis: In the present study, the accumulation of autophagolysosomes due to the augmentation of SQSTM1/p62 and the diminution of key autophagic biomarkers indicates the involvement of autophagy inhibition, which may have led to apoptosis and resulted in the follicular atresia in the ovary of HFD-HF diet-fed rats.